abstract：:Cutaneous adverse drug reactions are commonly seen in patients with anticancer drug treatment. Anticancer drugs, including chemotherapy, target therapy, and recent immunotherapy causing skin reactions ranging from mild skin rash to life-threatening severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson sy...

journal_title：Journal of immunology research

authors： Ng CY,Chen CB,Wu MY,Wu J,Yang CH,Hui RC,Chang YC,Lu CW

更新日期：2018-01-17 00:00:00

abstract：:Vaccination against human papillomavirus (HPV) has been progressively implemented in most developed countries for approximately 10 years. In order to increase the protection of the vaccines, a 9-valent vaccine (HPV9) was developed, which provides protection against nine types of the virus. Studies evaluating its safet...

journal_title：Journal of immunology research

authors： Costa APF,Cobucci RNO,da Silva JM,da Costa Lima PH,Giraldo PC,Gonçalves AK

更新日期：2017-01-01 00:00:00

abstract：:Epstein-Barr virus is a very common human virus that infects 90% of human adults. EBV replicates in epithelial and B cells and causes infectious mononucleosis. EBV infection is also linked to various cancers, including Burkitt's lymphoma and nasopharyngeal carcinomas, and autoimmune diseases such as multiple sclerosis...

journal_title：Journal of immunology research

authors： Alonso-Padilla J,Lafuente EM,Reche PA

更新日期：2017-01-01 00:00:00

abstract：:Latent tuberculosis infection (LTBI) is evidence of immunological control of tuberculosis. Dormancy survival regulator (DosR) regulon-encoded proteins may have a role in the maintenance of LTBI. T cell responses to Rv1733c, Rv0081, Rv1735c, and Rv1737c DosR regulon-encoded proteins were found to be most frequent among...

journal_title：Journal of immunology research

authors： Kimuda SG,Nalwoga A,Levin J,Franken KL,Ottenhoff TH,Elliott AM,Cose S,Andia-Biraro I

更新日期：2017-01-01 00:00:00

abstract：:Phosphotyrosine phosphatases (PTPs) constitute a complex family of enzymes that control the balance of intracellular phosphorylation levels to allow cell responses while avoiding the development of diseases. Despite the relevance of CD4 T cell polarisation and effector function in human autoimmune diseases, the expres...

journal_title：Journal of immunology research

authors： Castro-Sánchez P,Ramirez-Munoz R,Roda-Navarro P

更新日期：2017-01-01 00:00:00

abstract：:Human respiratory syncytial virus (RSV) is a common and highly contagious viral agent responsible for acute lower respiratory infection in infants. This pathology characterized by mucus hypersecretion and a disturbed T cell immune response is one of the major causes of infant hospitalization for severe bronchiolitis. ...

journal_title：Journal of immunology research

authors： Drajac C,Laubreton D,Riffault S,Descamps D

更新日期：2017-01-01 00:00:00

abstract：:Easy access to a vast collection of experimental data on immune epitopes can greatly facilitate the development of therapeutics and vaccines. The Immune Epitope Database and Analysis Resource (IEDB) was developed to provide such a resource as a free service to the biomedical research community. The IEDB contains epito...

journal_title：Journal of immunology research

authors： Fleri W,Vaughan K,Salimi N,Vita R,Peters B,Sette A

更新日期：2017-01-01 00:00:00

abstract：:Recruitment of human NK cells to porcine tissues has been demonstrated in pig organs perfused ex vivo with human blood in the early 1990s. Subsequently, the molecular mechanisms leading to adhesion and cytotoxicity in human NK cell-porcine endothelial cell (pEC) interactions have been elucidated in vitro to identify t...

journal_title：Journal of immunology research

authors： Puga Yung G,Schneider MKJ,Seebach JD

更新日期：2017-01-01 00:00:00

abstract：:A derivative formula, DGBX, which is composed of three herbs (Radix astragali, Radix Angelicae sinensis, and Coptis chinensis Franch), is derived from a famous Chinese herbal formula, Danggui Buxue Tang (DBT) (Radix astragali and Radix Angelicae sinensis). We aimed to investigate the effects of DGBX on the regulation ...

journal_title：Journal of immunology research

authors： Zhou J,Li X,Deng P,Wei Y,Liu J,Chen M,Xu Y,Zhang D,Zhu L,Lou L,Dong B,Jin Q,Chai L

更新日期：2017-01-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is characterized by deregulated activation of T and B cells, autoantibody production, and consequent formation of immune complexes. Liposomes with nonbilayer phospholipid arrangements (NPA), induced by chlorpromazine, procainamide, or manganese, provoke a disease resembling human lup...

journal_title：Journal of immunology research

authors： Zárate-Neira LÁ,Sánchez-Barbosa S,Pedroza-Torres A,Reséndiz-Mora A,Wong C,Baeza I,Pérez-Plasencia C,Wong-Baeza C

更新日期：2017-01-01 00:00:00

abstract：:Background. Systemic lupus erythematosus (SLE) is an autoimmune disease with great heterogeneity in pathogenesis and clinical symptoms. Rheumatoid factor (RF) is one key indicator for rheumatoid arthritis (RA) while immunoglobulin E (IgE) is associated with type I hypersensitivity. To better categorize SLE subtypes, w...

journal_title：Journal of immunology research

authors： Wu Y,Cai B,Zhang J,Shen B,Huang Z,Tan C,Baan CC,Wang L

更新日期：2017-01-01 00:00:00

abstract：:Although cancer immunotherapy has shown significant promise in mediating efficacious responses, it remains encumbered by tumor heterogeneity, loss of tumor-specific antigen targets, and the regulatory milieu both regionally and systemically. Cross talk between the innate and adaptive immune response may be requisite t...

journal_title：Journal of immunology research

authors： Sayour EJ,Mitchell DA

更新日期：2017-01-01 00:00:00

abstract：:Adverse drug reactions (ADRs) remain a common and major problem in healthcare. Severe cutaneous adverse drug reactions (SCARs), such as Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) with mortality rate ranges from 10% to more than 30%, can be life threatening. A number of recent studies demonstrated ...

journal_title：Journal of immunology research

authors： Fan WL,Shiao MS,Hui RC,Su SC,Wang CW,Chang YC,Chung WH

更新日期：2017-01-01 00:00:00

abstract：:Although it is known that systemic form of lupus erythematosus (LE) and metabolic syndrome (MetS) are frequently observed together, there are no published reports on MetS in patients with skin-restricted LE. We aimed to compare the frequencies of MetS and its components in discoid LE (DLE) with the non-DLE control gro...

journal_title：Journal of immunology research

authors： Akarsu S,Ozbagcivan O,Semiz F,Aktan S

更新日期：2017-01-01 00:00:00

abstract：:The present study was aimed at determining the activity of aqueous and methanolic extracts of Tinospora cordifolia (AETC and METC) against Salmonella typhimurium. In vitro anti-Salmonella activity of T. cordifolia was determined through the broth dilution and agar well diffusion assays. The immune-stimulating potentia...

journal_title：Journal of immunology research

authors： Alsuhaibani S,Khan MA

更新日期：2017-01-01 00:00:00

abstract：:Reports suggesting a pathogenic role of autoantibodies directed against glutamic acid decarboxylase 65 (GAD65Abs) in cerebellar ataxias (CAs) are reviewed, and debatable issues such as internalization of antibodies by neurons and roles of epitopes are discussed. GAD65 is one of two enzymes that catalyze the conversion...

journal_title：Journal of immunology research

authors： Mitoma H,Manto M,Hampe CS

更新日期：2017-01-01 00:00:00

abstract：:The gastrointestinal microbiota plays a critical role in nutritional, metabolic, and immune functions in infants and young children and has implications for future lung health status. Understanding the role of intestinal dysbiosis in chronic lung disease progression will provide opportunities to design early intervent...

journal_title：Journal of immunology research

authors： Ranucci G,Buccigrossi V,de Freitas MB,Guarino A,Giannattasio A

更新日期：2017-01-01 00:00:00

abstract：:The roots of Euphorbia kansui, which belong to the family Euphorbiaceae, have been used as a traditional medicine for the treatment of various diseases such as diabetes, ascites, and leukemia. Recently, it was reported that the methylene chloride fraction of E. kansui radix (EKC) regulated the differentiation of Th17 ...

journal_title：Journal of immunology research

authors： Kim SJ,Jang YW,Hyung KE,Lee DK,Hyun KH,Park SY,Park ES,Hwang KW

更新日期：2017-01-01 00:00:00

abstract：:The human leukocyte antigen-G (HLA-G) is considered an immune checkpoint molecule involved in tumor immune evasion. Hypoxia and the metabolic sensor hypoxia-inducible factor 1 (HIF-1) are hallmarks of metastasization, angiogenesis, and intense tumor metabolic activity. The purpose of this review was to examine origina...

journal_title：Journal of immunology research

authors： Garziera M,Scarabel L,Toffoli G

更新日期：2017-01-01 00:00:00

abstract：:Therapeutic monoclonal antibodies (mAbs) represent a milestone in pharmacological development. Their superiority is based on the combination of high specificity, low toxicity, and long half-life that characterizes biologics. If biologics have Achilles' heel, it is their potential immunogenicity. To better understand t...

journal_title：Journal of immunology research

authors： Boysen M,Schlicksupp L,Dreher I,Loebbert R,Richter M

更新日期：2016-01-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that is characterized by synovial hyperplasia and progressive joint destruction. The activation of RA synovial fibroblasts (SFs), also called fibroblast-like synoviocytes (FLS), contributes significantly to perpetuation of the disease. Genetic and ...

journal_title：Journal of immunology research

authors： Araki Y,Mimura T

更新日期：2016-01-01 00:00:00

abstract：:Purified protein vaccines often require adjuvants for efficient stimulation of immune responses. There is no licensed mucosal adjuvant on the market to adequately boost the immune response to purified antigens for intranasal applications in humans. Bacterial outer membrane vesicles (OMV) are attractive candidates pote...

journal_title：Journal of immunology research

authors： Pritsch M,Ben-Khaled N,Chaloupka M,Kobold S,Berens-Riha N,Peter A,Liegl G,Schubert S,Hoelscher M,Löscher T,Wieser A

更新日期：2016-01-01 00:00:00

abstract：:Background. Millions of people are infected with hepatitis C virus (HCV) worldwide and 30% spontaneously clear the infection. Reasons for HCV clearance without antiviral treatment are not well understood. Methods. Blood was collected for DNA analysis from patients with chronic HCV infection or evidence of spontaneous ...

journal_title：Journal of immunology research

authors： Waldron PR,Belitskaya-Lévy I,Chary A,Won J,Winters M,Monto A,Ryan J,Lazzeroni LC,Holodniy M

更新日期：2016-01-01 00:00:00

abstract：:Reduning injection is a traditional Chinese medicine injection which has multiple functions such as clearing heat, dispelling wind, and detoxification. Although Reduning injection was widely utilized, reports of its allergenicity emerged one after another. However, there is little research on its allergenic substances...

journal_title：Journal of immunology research

authors： Wang F,Li CY,Zheng YF,Li HY,Xiao W,Peng GP

更新日期：2016-01-01 00:00:00

abstract：:Extracellular matrix metalloproteases and the fibrinolytic system are important protease systems interacting with each other in charge of remodeling and recycling of tissues. Their role in tumor invasion and metastasis is often discussed. In this study several metalloproteases such as MMP-1, MMP-3, MMP-9, and TIMP-1 t...

journal_title：Journal of immunology research

authors： Barajas-Castañeda LM,Cortés-Gutiérrez E,García-Rodríguez FM,Campos-Rodríguez R,Lara-Padilla E,Enríquez-Rincón F,Castro-Mussot ME,Figueroa-Arredondo P

更新日期：2016-01-01 00:00:00

abstract：:Dopamine (DA), a neurotransmitter in the central nervous system (CNS), has modulatory functions at the systemic level. The peripheral and central nervous systems have independent dopaminergic system (DAS) that share mechanisms and molecular machinery. In the past century, experimental evidence has accumulated on the p...

journal_title：Journal of immunology research

authors： Arreola R,Alvarez-Herrera S,Pérez-Sánchez G,Becerril-Villanueva E,Cruz-Fuentes C,Flores-Gutierrez EO,Garcés-Alvarez ME,de la Cruz-Aguilera DL,Medina-Rivero E,Hurtado-Alvarado G,Quintero-Fabián S,Pavón L

更新日期：2016-01-01 00:00:00

abstract：:Neuropathic pain (NPP) is intolerable, persistent, and specific type of long-term pain. It is considered to be a direct consequence of pathological changes affecting the somatosensory system and can be debilitating for affected patients. Despite recent progress and growing interest in understanding the pathogenesis of...

journal_title：Journal of immunology research

authors： Wan W,Cao L,Khanabdali R,Kalionis B,Tai X,Xia S

更新日期：2016-01-01 00:00:00

abstract：:In organ transplantation, alloantigens are taken up by antigen presenting cells and presented via the indirect pathway to T-cells which in turn can induce allograft rejection. Monitoring of these T-cells is of major importance; however no reliable assay is available to routinely monitor indirect allorecognition. Recen...

journal_title：Journal of immunology research

authors： Breman E,Ruben JM,Franken KL,Heemskerk MH,Roelen DL,Claas FH,van Kooten C

更新日期：2016-01-01 00:00:00

abstract：:Background. U65, a self-aggregating peptide scaffold, traps fused protein antigens in yeast cells. Conversion to Yeast Cell Particle (YCP) vaccines by partial removal of surface mannoproteins exposes β-glucan, mediating efficient uptake by antigen-presenting cells (APCs). YCP vaccines are inexpensive, capable of rapid...

journal_title：Journal of immunology research

authors： Tipper DJ,Szomolanyi-Tsuda E

更新日期：2016-01-01 00:00:00

abstract：:Circulating T follicular helper (cTfh) cells are known to be involved in numerous immune-mediated diseases, but their pathological role in psoriasis is less fully investigated. Herein, we aimed to identify whether cTfh cells contributed to the pathogenesis of psoriasis. The frequency and function of cTfh cells were co...

journal_title：Journal of immunology research

authors： Wang Y,Wang L,Yang H,Yuan W,Ren J,Bai Y

更新日期：2016-01-01 00:00:00

abstract：:Intestinal inflammation is a harmful condition in fish that can be triggered by the ingestion of soybean meal. Due to the positive costs-benefits ratio of including soybean meal in farmed fish diets, identifying additives with intestinal anti-inflammatory effects could contribute to solving the issues caused by this p...

journal_title：Journal of immunology research

authors： Ulloa PE,Solís CJ,De la Paz JF,Alaurent TG,Caruffo M,Hernández AJ,Dantagnan P,Feijóo CG

更新日期：2016-01-01 00:00:00

abstract：:Aims. In the present study, we aimed to assess the concentrations of IL-13 and IL-17 in serum of patients with early rheumatoid arthritis (eRA), the investigation of correlation between the concentrations of these cytokines and disease activity score, and the concentration of some autoantibodies and the evaluation of ...

journal_title：Journal of immunology research

authors： Siloşi I,Boldeanu MV,Cojocaru M,Biciuşcă V,Pădureanu V,Bogdan M,Badea RG,Avramescu C,Petrescu IO,Petrescu F,Siloşi CA

更新日期：2016-01-01 00:00:00

abstract：:Bacterial vaginosis (BV), the most common genital infection in reproductive-aged women, is associated with increased risk of sexually transmitted infections. Its etiology remains unclear, especially the role of Gardnerella (G.) vaginalis, an anaerobic bacterium characteristic of the BV-alteration of the vaginal ecosys...

journal_title：Journal of immunology research

authors： Bertran T,Brachet P,Vareille-Delarbre M,Falenta J,Dosgilbert A,Vasson MP,Forestier C,Tridon A,Evrard B

更新日期：2016-01-01 00:00:00

abstract：:Reconstitution of the hematopoietic system during immune responses and immunological and neoplastic diseases or upon transplantation depends on the emergent differentiation of hematopoietic stem/progenitor cells within the bone marrow. Although in the last decade the use of dialyzable leukocyte extracts (DLE) as suppo...

journal_title：Journal of immunology research

authors： Ramírez-Ramírez D,Vadillo E,Arriaga-Pizano LA,Mayani H,Estrada-Parra S,Velasco-Velázquez MA,Pérez-Tapia SM,Pelayo R

更新日期：2016-01-01 00:00:00

abstract：:In vitro differentiation of mesenchymal stromal cells (MSC) into osteocytes (human differentiated osteogenic cells, hDOC) before implantation has been proposed to optimize bone regeneration. However, a deep characterization of the immunological properties of DOC, including their effect on dendritic cell (DC) function,...

journal_title：Journal of immunology research

authors： Trabanelli S,La Manna F,Romano M,Salvestrini V,Cavo M,Ciciarello M,Lemoli RM,Curti A

更新日期：2015-01-01 00:00:00

abstract：:Systemic lupus erythematosus is characterized by dysregulated activation of T and B cells and autoantibodies to nuclear antigens and, in some cases, lipid antigens. Liposomes with nonbilayer phospholipid arrangements induce a disease resembling human lupus in mice, including IgM and IgG antibodies against nonbilayer p...

journal_title：Journal of immunology research

authors： Wong-Baeza C,Tescucano A,Astudillo H,Reséndiz A,Landa C,España L,Serafín-López J,Estrada-García I,Estrada-Parra S,Flores-Romo L,Wong C,Baeza I

更新日期：2015-01-01 00:00:00

abstract：:Antiphospholipid syndrome (APS) is characterized by development of venous and/or arterial thrombosis and pregnancy morbidity. Biological criteria are the persistent presence of lupus anticoagulant (LA) and/or anti-cardiolipin (aCL) and/or anti-B2GP1 autoantibodies' positivity. The assays' performances are of crucial i...

journal_title：Journal of immunology research

authors： Sénant M,Rostane H,Fernani-Oukil F,Hosking F,Bellery F,Courchinoux A,Tartour E,Darnige L,Dragon-Durey MA

更新日期：2015-01-01 00:00:00

abstract：:Bone disease in rheumatoid arthritis (RA) is a complex phenomenon where genetic risk factors have been partially evaluated. The system formed by receptor activator for nuclear factor-κB (RANK), receptor activator for nuclear factor-κB ligand (RANKL), and osteoprotegerin (OPG): RANK/RANKL/OPG is a crucial molecular pat...

journal_title：Journal of immunology research

authors： Zavala-Cerna MG,Moran-Moguel MC,Cornejo-Toledo JA,Gonzalez-Montoya NG,Sanchez-Corona J,Salazar-Paramo M,Nava-Zavala AH,Aguilar-Chavez EA,Alcaraz-Lopez MF,Gonzalez-Sanchez AG,Gonzalez-Lopez L,Gamez-Nava JI

更新日期：2015-01-01 00:00:00

abstract：:Toll-like receptors (TLRs) are known to detect a defined spectrum of microbial structures. However, the knowledge about the specificity of teleost Tlr factors for distinct pathogens is limited so far. We measured baseline expression profiles of 18 tlr genes and associated signaling factors in four immune-relevant tiss...

journal_title：Journal of immunology research

authors： Brietzke A,Korytář T,Jaros J,Köllner B,Goldammer T,Seyfert HM,Rebl A

更新日期：2015-01-01 00:00:00

abstract：:Many immune-based intestinal disorders, such as ulcerative colitis and Crohn's disease, as well as other illnesses, may have the intestines as an initial cause or aggravator in the development of diseases, even apparently not correlating directly to the intestine. Diabetes, obesity, multiple sclerosis, depression, and...

journal_title：Journal of immunology research

authors： Maranduba CM,De Castro SB,de Souza GT,Rossato C,da Guia FC,Valente MA,Rettore JV,Maranduba CP,de Souza CM,do Carmo AM,Macedo GC,Silva Fde S

更新日期：2015-01-01 00:00:00